Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy . Gemcitabine induces apoptosis through the activation of p38 MAPK . Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer . Gemcitabine can be used for cancer research, such as pancreatic cancer , non-small cell lung cancer , and breast cancer .
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