ADS1017 is the antagonist for histamine receptor and muscarinic receptor , that exhibits good affinities to hH3R, hH4R, hM2R and hM4R with pK i of 6.8, 5.5, 7.4 and 7.2. ADS1017 exhibits analgesic and anti-allodynic efficacy in mice Capsaicin ( HY-10448 )-or Oxaliplatin ( HY-17371 )-induced pain models.
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