KAI-11101

Overview

KAI-11101 is the inhibitor for dual leucine zipper kinase ( DLK , MAP3K12 ) with a K i of 0.7 nM. KAI-11101 inhibits Paclitaxel ( HY-B0015 )-induced cJun phosphorylation ( IC 50 =95 nM) and thus inhibits the activation of MAPK pathway. KAI-11101 is blood brain barrier penetrable and can be further investigated for its neuroprotective property.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > MAP3K | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-170484
• CAS No.: 3099935-02-8
• Molecular Formula: C21H23F4N5O3
• Molecular Weight: 469.43
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source