VU6024578

Overview

VU6024578 (BI02982816) is a selective, orally active positive allosteric modulator (PAM) for metabotropic glutamate receptor ( mGluR1 ), that activates human mGluR1 and rat mGluR1 with EC 50 of 54 nM and 46 nM. VU6024578 exhibits antipsychotic activity in rats amphetamine-induced hyperactivity models and MK-801 ( HY-15084B )-induced novel object recognition (NOR) models. VU6024578 is blood brain barrier penetrable.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mGluR

Product Information

• Catalog No.: HY-170499
• CAS No.: 3100913-05-8
• Molecular Formula: C20H18ClN5O2
• Molecular Weight: 395.84
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source