FUT8-IN-1 (Compound 37) is an inhibitor for α-1,6-fucosyltransferase ( FUT8 ) with an K D of 49 nM and an IC 50 of ca . 50 µM. FUT8-IN-1 generates a highly active naphthoquinone imine intermediate in the presence of FUT8 , and inhibits the enzymatic activity of FUT8 .
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Glucosylceramide Synthase (GCS)
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