P162-0948

Overview

P162-0948 is a selective CDK8 inhibitor with an IC 50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Infection | Products > Signaling Pathways > CDK | Products > Signaling Pathways > TGF-beta/Smad

Product Information

• Catalog No.: HY-170813
• CAS No.: 1358201-44-1
• Molecular Formula: C20H15FN4O2
• Molecular Weight: 362.36
• Purity: 99.98%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source