SMD-3236

Overview

SMD-3236 is a SMARCA2 PROTAC degrader with a DC 50 of 0.5 nM, a D max of 98%, and an IC 50 of 42.2 nM against human SMARCA2 . SMD-3236 induces proteasome- and ubiquitin-like modification-dependent degradation of SMARCA2 protein by binding to SMARCA2 and VHL-1 . SMD-3236 inhibits the growth of SMARCA4 -deficient cancer cells. SMD-3236 induces significant and persistent depletion of SMARCA2 in tumor tissues. SMD-3236 suppresses tumor growth in SMARCA4 -deficient human cancer xenograft models. SMD-3236 can be used in research related to SMARCA4 -deficient cancers such as melanoma, non-small cell lung cancer , and acute myeloid leukemia. (Pink: SMARCA2 ligand ( HY-170817 ); Blue: VHL ligand ( HY-170826 ); Black: linker ( HY-170825 )).

Application

Products | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Melanoma | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SWI/SNF Complex

Product Information

• Catalog No.: HY-170824
• CAS No.: 3033586-31-8
• Molecular Formula: C61H75ClN10O5S
• Molecular Weight: 1095.83
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source