SMD-1087

Overview

SMD-1087 is a PROTAC that selectively targets SMARCA2 ( DC 50 =8 nM, D max =89%) and SMARCA4 with a DC 50 of 1 μM. SMD-1087 consists of the E3 ligase ligand (S,R,S)-AHPC-Me (blue part) ( HY-112078 ), the target protein ligand SMI-1074 (red part) ( HY-170817 ), and the PROTAC linker (1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate (black part) ( HY-W890392 ). Among them, its target protein ligand + Linker part corresponds to SMARCA2 Ligand-Linker Conjugate-1 (HY-170829). (Pink: SMARCA2 ligand ( HY-170817 ); Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-W890392 )).

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Others | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SWI/SNF Complex

Product Information

• Catalog No.: HY-170828
• CAS No.: 3033586-04-5
• Molecular Formula: C56H68ClN7O5S
• Molecular Weight: 986.70
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source