AH078

Overview

AH078 is a PROTAC -based CK1δ/ε degrader ( DC 50 =0.55 μM, D max =70%) that lacks subtype selectivity between CK1δ and CK1ε . AH078 induces target protein degradation either by recruiting the CUL4-CRBN E3 ligase complex and proteasome , or via the VHL - and ubiquitin-dependent pathway. AH078 also exhibits selectivity for CK1α , and is widely applicable to research related to colon cancer , pancreatic cancer , breast cancer , ovarian cancer , chronic lymphocytic leukemia, acute myeloid leukemia, glioma, and metastatic breast adenocarcinoma. (Pink: CK1δ and CK1ε ligand ( HY-170860 ); Blue: VHL ligand ( HY-125845B ); Black: linker ( HY-W001958 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Casein Kinase

Product Information

• Catalog No.: HY-170859
• CAS No.: 3110370-06-1
• Molecular Formula: C51H60F2N10O5S
• Molecular Weight: 963.15
• Purity: 99.73%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source