BETd-260

Overview

BETd-260 (ZBC 260) is a PROTAC connected by ligands for Cereblon and BET , with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line. BETd-260 potently suppresses cell viability and robustly induces apoptosis in hepatocellular carcinoma (HCC) cells. (Pink: BET ligand ( HY-112429 ); Blue: Cereblon ligand ( HY-43722 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-101519
• CAS No.: 2093388-62-4
• Molecular Formula: C43H46N10O6
• Molecular Weight: 798.89
• Purity: 99.68%
• Storage: -80°C, protect from light, stored under nitrogen
• Solubility: ≥ 0.83 mg/mL (1.04 mM); Clear solution
• Availability: In-stock

Source

Original product source