Antidepressant agent 8 (Compound 1f) is a selective antagonist for the NMDA receptor GluN1/2A with an IC 50 of 2.94 μmol/L. Antidepressant agent 8 exhibits antidepressant-like effects in Hydrocortisone ( HY-N0583 )-induced zebrafish depression model. Antidepressant agent 8 can cross blood-brain barrier.
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