Pellotine is an alkaloid that can be isolated from Lophophora . Pellotine is the inverse agonist for 5-HT7 receptor with an EC 50 of 291 nM. Pellotine exhibits good affinity to 5-HT1DR and 5-HT6R with K i of 117 nM and 170 nM. Pellotine reduces intracellular cAMP levels, thereby reducing neuronal excitability and neurotransmitter release.
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