(Rac)-P1D-34

Overview

PROTAC PIN1 degrader-2 (1) is a PROTAC -based PIN1 degrader (Pink: PIN1 ligand HY-171442, Blue: cereblon ligand Thalidomide ( HY-14658 ), Black: linker HY-W014883). PROTAC PIN1 degrader-2 (1) possesses anti-cancer activity, with IC 50 values of 2248 nM (MV-4-11 cells), 3984 nM (MOLM-13), 3925 nM (HL-60), 3925 nM (HL-60), 3925 nM (HL-60), 3925 nM (HL-60) and 3925 nM (HL-60) respectively. (Pink: PIN1 ligand ( HY-171442 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-W014883 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > PIN1

Product Information

• Catalog No.: HY-171334
• CAS No.: 2957895-04-2
• Molecular Formula: C40H59ClN6O9S
• Molecular Weight: 835.45
• Purity: 99.45%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.99 mM); Clear solution
• Availability: In-stock

Source

Original product source