SKP-451

Overview

SKP-451 is an ATP-sensitive potassium (K + ) channel agonist. SKP-451 activates the ATP-sensitive K + channels, promotes the efflux of K + , causes membrane hyperpolarization, and inhibits the influx of Ca 2+ , thereby relaxing the vascular smooth muscle. SKP-451 relaxs the canine coronary artery, rabbit basilar artery, and vertebral artery. SKP-451 also reduces the mean arterial blood pressure of conscious spontaneously hypertensive rats (SHR). SKP-451 is promising for research of cardiovascular diseases.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Potassium Channel

Product Information

• Catalog No.: HY-171469
• CAS No.: 181137-41-7
• Molecular Formula: C17H18N2O6
• Molecular Weight: 346.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source