R1-ICR-5

Overview

R1-ICR-5 is a highly selective RIPK1 PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1 , which in turn dysregulates the TNFR1 and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB , MAPK and IFN , and simultaneously promotes RIPK3 activation and necroptosis ( necroptosis ). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation. (Pink: RIPK1 ligand ( HY-128348 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-W012241 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > TNF Receptor

Product Information

• Catalog No.: HY-171658
• CAS No.: 3070346-91-4
• Molecular Formula: C54H70N8O7S2
• Molecular Weight: 1007.31
• Purity: 98.73%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.48 mM); Clear solution
• Availability: In-stock

Source

Original product source