KMS99220

Overview

KMS99220 is an orally active, blood-brain barrier-permeable activator of the Nrf2 inhibitory protein Keap-1 . KMS99220 enhances the activity of AMPK , activates the Nrf2 signaling pathway, and reduces the phosphorylation of IκB , nuclear translocation of NFκB , as well as the phosphorylation levels of JNK , IKK and p38 MAPK via HO-1 . KMS99220 binds to Keap1 to trigger the nuclear translocation of Nrf2 , induces the expression of HO-1 , NQO1 , GCLC , GCLM and proteasome subunits; enhances proteasomal enzymatic activity; inhibits iNOS expression, nitric oxide production and IL-1β generation; attenuates microglial activation; reduces α-synuclein aggregation; and prevents dopaminergic neuron degeneration and motor dysfunction. KMS99220 prevents the degeneration of dopaminergic neurons in the substantia nigra, induces the expression of Nrf2 downstream target genes, and effectively ameliorates associated motor dysfunction in a mouse model of Parkinson's disease. KMS99220 is applicable to research related to Parkinson's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > JNK | Products > Signaling Pathways > IKK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > α-synuclein | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > AMPK

Product Information

• Catalog No.: HY-171705
• CAS No.: 1478585-60-2
• Molecular Formula: C23H25ClF3NO3
• Molecular Weight: 455.90
• Purity: 99.48%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 5 mg/mL (10.97 mM); Clear solution
• Availability: In-stock

Source

Original product source