BU72 is a highly potent and long-acting agonist of μ and κ opioid receptors , and also has a partial agonist effect on δ opioid receptors ( EC 50 values are 0.054, 0.033, and 0.58 nM, respectively). BU72 has a strong and long-lasting analgesic effect, which is mainly mediated by μ opioid receptors. BU72 has a long-lasting activity and can partially reverse the analgesic effect of morphine. BU72 can be used in the study of opioid dependence.
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