SK2188

Overview

SK2188 (JB325) is a highly efficient and selective PROTAC degrader targeting AURKA ( DC 50 = 3.9 nM). SK2188 induces DNA damage and cell apoptosis . SK2188 indirectly degrades MYCN , inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma. (Pink: Aurora Kinase ligand ( HY-13252 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-W008005 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Aurora Kinase

Product Information

• Catalog No.: HY-171767
• CAS No.: 3038446-94-2
• Molecular Formula: C43H46ClFN6O10S
• Molecular Weight: 893.38
• Purity: 99.87%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.80 mM); Clear solution
• Availability: In-stock

Source

Original product source