SK2187

Overview

SK2187 (JB301) is a selective AURKA PROTAC degrader with a DC 50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC 50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma. (Pink: Aurora Kinase ligand ( HY-13252 ); Blue: Cereblon ligand ( HY-103597 ); Black: linker ( HY-W015088 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Aurora Kinase

Product Information

• Catalog No.: HY-171768
• CAS No.: 3038446-91-9
• Molecular Formula: C45H49ClFN7O11S
• Molecular Weight: 950.43
• Purity: 95.81%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.63 mM); Clear solution
• Availability: In-stock

Source

Original product source