PROTAC HMGCR Degrader-1

Overview

PROTAC HMGCR Degrader-1 is an orally active HMGCR PROTAC degrader with IC 50 of 1.32 μM. PROTAC HMGCR Degrader-1 is a lactone prodrug of PROTAC HMGCR Degrader-2 ( HY-181134 ). PROTAC HMGCR Degrader-1 achieves high plasma exposure of the active ingredient leading to robust HMGCR degradation and demonstrating promising cholesterol-lowering efficacy in vivo. PROTAC HMGCR Degrader-1 can be used for hyperlipidemia research.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Hyperlipidemia | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > HMG-CoA Reductase (HMGCR)

Product Information

• Catalog No.: HY-171823
• CAS No.: 2715104-45-1
• Molecular Formula: C53H77N5O9S
• Molecular Weight: 960.27
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source