MS105

Overview

MS105 (YX39-105) is an orally active and selective protein tyrosine kinase 6 ( PTK6 ) ( BRK ) PROTAC degrader. MS105 recruits VHL E3 ligase via a VHL ligand moiety, promotes PTK6 ubiquitination and proteasomal degradation, inhibits the proliferation and migration of breast cancer cells, and induces apoptosis . MS105 shows potential for use in breast cancer research. (Pink: BRK Target protein ligand; Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-W105727 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Tyrosinase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-171830
• CAS No.: 2408339-39-7
• Molecular Formula: C56H70FN13O6S
• Molecular Weight: 1072.30
• Purity: 98.27%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.33 mM); Clear solution
• Availability: In-stock

Source

Original product source