TD-6301 is a bladder-selective M 2/4 muscarinic receptor antagonist. TD-6301 binds to and blocks M 2/4 muscarinic receptors with high selectivity, especially human M 2 receptors with strong affinity ( K i = 0.36 nM). TD-6301 inhibits volume-induced bladder contractions ( ID 50 = 0.075 mg/kg). TD-6301 can be used in the research of overactive bladder.
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Endocrinology | Products > Signaling Pathways > mAChR
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