FC-14369

Overview

FC-14369 is a PROTAC degrader targeting the HIV-1 Nef protein, with a DC 50 value of 160 nM. Through its bifunctional structure, FC-14369 binds to Nef and the Cereblon E3 ubiquitin ligase , induces Nef ubiquitination and proteasomal degradation, restores the expression of cell-surface CD4 and MHC-I, and inhibits HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS. FC-14369 is applicable to studies related to HIV-1 infection . (Pink: HIV-1 Nef ligand ( HY-171862 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker).

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Viral Infection | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Infection | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > HIV

Product Information

• Catalog No.: HY-171860
• CAS No.: 3066894-28-5
• Molecular Formula: C42H34ClF3N8O7
• Molecular Weight: 855.22
• Purity: 97.85%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Availability: In-stock

Source

Original product source