12-Nitrolinoleate

Overview

12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is an activator for peroxisome proliferator-activated receptor γ ( PPARγ ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC 50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS ( HY-D1056 )-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6 , TNF-α and CCL2 induced by LPS.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-171895
• CAS No.: 774603-05-3
• Molecular Formula: C18H31NO4
• Molecular Weight: 325.44
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source