JB300

Overview

JB300 is a highly selective Aurora A degrader based on PROTAC technology ( DC 50 =30 nM). JB300 can be used for tumor research. JB300 consists of PROTAC target protein ligand MK-5108 ( HY-13252 ) (pink part), E3 ligase ligand Thalidomide-O-COOH ( HY-103597 ) (blue part) and PROTAC Linker Boc-NH-PEG2-C2-NH2 ( HY-W008474 ) (black part), of which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-O-COOH -NH2-C2-PEG2-NH-Boc ( HY-172145 ). (Pink: Aurora A ligand ( HY-13252 ); Blue: Cereblon ligand ( HY-103597 ); Black: linker ( HY-W008474 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Aurora Kinase

Product Information

• Catalog No.: HY-172144
• CAS No.: 3038446-90-8
• Molecular Formula: C43H45ClFN7O10S
• Molecular Weight: 906.37
• Purity: 98%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source