AMPTX-1

Overview

AMPTX-1 is a selective, orally active, covalent reversible BRD9 molecular glue degrader with a DC 50 of 0.05 nM. AMPTX-1 selectively recruits BRD9 to the E3 ligase DCAF16 . AMPTX-1 forms a ternary complex with BRD9 and a reversible covalent adduct with Cys58 on the surface of DCAF16 . AMPTX-1 mediates BRD9 degradation via the proteasome and Cullin RING E3 ligase pathways. AMPTX-1 can be used in the research of solid tumors and hematological malignancies.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-172615
• CAS No.: 3033019-04-1
• Molecular Formula: C42H53N5O4
• Molecular Weight: 691.90
• Purity: 98.00%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source