(E/Z)-ABP/PPAR modulator 1

Overview

(E/Z)-ABP/PPAR modulator 1 is a mixture of the E and Z isomers of ABP/PPAR modulator 1 ( HY-172883 ). ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator ( IC 50 s of 0.65 μM and 1.08 μM for FABP1 and FABP4, EC 50 s of 9.19 μM, 2.20 μM and 1.58 μM for PPARα , PPARγ and PPARδ ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model.

Application

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Product Information

• Catalog No.: HY-172883A
• CAS No.: 3104894-76-7
• Molecular Formula: C33H39NO7
• Molecular Weight: 561.67
• Purity: 97.22%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.45 mM); Clear solution
• Availability: In-stock

Source

Original product source