Nedisertib

Overview

Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase ( DNA-PK ) inhibitor with an IC 50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2 , capable of reversing ABCG2 -mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity.

Application

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Product Information

• Catalog No.: HY-101570
• CAS No.: 1637542-33-6
• Molecular Formula: C24H21ClFN5O3
• Molecular Weight: 481.91
• Purity: 99.70%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: 5.56 mg/mL (11.54 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source