MS9024

Overview

MS9024 is a selective DNMT1 Molecular glue degrader with a DC 50 of 35 nM. MS9024 degrades DNMT1 in a concentration-, time- and proteasome-dependent manner without altering DNMT1 transcription. MS9024 mediates degradation via HECT E3 ligase and/or UHRF1 , but not via lysosomes or Cullin RING E3 ligase . MS9024 can be used in the research of colorectal cancer , breast cancer and non-small cell lung cancer .

Application

Products | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA Methyltransferase | Products > Signaling Pathways > Molecular Glues

Product Information

• Catalog No.: HY-173002
• CAS No.: 3107482-42-5
• Molecular Formula: C21H22N6O2S
• Molecular Weight: 422.50
• Purity: 99.83%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source