GI-Y2

Overview

GI-Y2 is an orally active, selective Gasdermin D (GSDMD) inhibitor ( K d = 36.0 μM) with anti- pyroptosis activity. GI-Y2 targets GSDMD, impairs membrane anchoring of GSDMD-NT, and blocks GSDMD‑dependent lipid binding and pore formation. GI-Y2 suppresses GSDMD‑dependent pyroptosis and inflammation, mitigates atherosclerosis and cardiac injury, boosts cell survival, and reduces IL‑1β/IL‑18 secretion. GI-Y2 can be used for the research of atherosclerosis and septic myocardial injury.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-173234
• CAS No.: 1008710-58-4
• Molecular Formula: C18H14N2O6S
• Molecular Weight: 386.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source