HEMTAC WEE1 degrader-1

Overview

HEMTAC WEE1 degrader-1 is a HSP90-mediated targeting chimera (HEMTAC) degrader of WEE1 ( HSP90 enzyme inhibitory activity is IC 50 : 16.76 nM). HEMTAC WEE1 degrader-1 promotes the ubiquitination and degradation of WEE1 . HEMTAC WEE1 degrader-1 blocks the G2/M cell cycle. HEMTAC WEE1 degrader-1 has anticancer activity in acute myeloid leukemia (AML) patient-derived xenograft (PDX) models. HEMTAC WEE1 degrader-1 can be used in AML research. (Pink: HSP90 binder; Blue: WEE1 ligand; Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Hsp-targeting Chimeras | Products > Signaling Pathways > Wee1 | Products > Signaling Pathways > HSP

Product Information

• Catalog No.: HY-173320
• CAS No.: 3002417-64-0
• Molecular Formula: C57H71N15O6
• Molecular Weight: 1062.27
• Purity: 99.78%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.35 mM); Clear solution
• Availability: In-stock

Source

Original product source