TLR4-IN-2

Overview

TLR4-IN-2 (Compound Racemic-11k) is inhibitors of TLR4 , JNK , and NF-κB . TLR4-IN-2 inhibits NO production in LPS-stimulated RAW264.7 cells with an IC 50 value of 23.2 µM. TLR4-IN-2 exerts anti-inflammatory activity by inhibiting TLR4 expression, reducing JNK phosphorylation, thereby suppressing the activation of NF-κB , blocking the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2 , and decreasing the production of inflammatory mediators such as NO, PGE 2, and TNF-α. TLR4-IN-2 is promising for research of inflammatory diseases, such as rheumatoid arthritis and various inflammatory disorders.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > JNK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > COX

Product Information

• Catalog No.: HY-173388
• CAS No.: 1019984-44-1
• Molecular Formula: C23H20O3
• Molecular Weight: 344.40
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source