P2Y 14 R antagonist 4 (Compound 25l) is an orally active P2Y 14 R antagonist ( IC 50 : 5.6 nM) with superior binding affinity to P2Y 14 R over PPTN. P2Y 14 R antagonist 4 has anti-inflammatory activity and reduces LPS ( HY-D1056 )-induced proinflammatory cytokines (IL-1β, IL-6 , and TNF-α) release.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > P2Y Receptor | Products > Signaling Pathways > Interleukin Related
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