Insecticidal agent 21 (Compound 6) is an insecticide that is effective against Culex pipiens larvae ( LC 50 : 0.4 μg/mL). Insecticidal agent 21 achieves multi-target neurotoxicity by inhibiting acetylcholinesterase ( AChE ) and simultaneously targeting other neural receptors (nicotinic acetylcholine receptors ( nAChR ), voltage-gated sodium channels ( VGSC ), and γ-aminobutyric acid receptors ( GABAAR )). Insecticidal agent 21 has a strong insecticidal effect and can be used in the development of new insecticides to address the problem of mosquito resistance to traditional insecticides.
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