PROTAC STING degrader-3

Overview

PROTAC STING degrader-3 is a STING PROTAC degrader ( DC 50 : 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI). (Pink: STING ligand ( HY-47709 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > STING | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-173414
• CAS No.: 3109967-69-0
• Molecular Formula: C37H36N8O10
• Molecular Weight: 752.73
• Purity: 98.04%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.32 mM); Clear solution
• Availability: In-stock

Source

Original product source