JNJ-9676

Overview

JNJ-9676 is an orally active Coronavirus M protein inhibitor and selective Sarbecovirus inhibitor. JNJ-9676 binds to the M protein dimer and forces the protein into an alternative conformational state with a compound-induced binding pocket. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2 , SARS-CoV and Sarbecovirus strains from bat and pangolin zoonotic origin.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > SARS-CoV-2 Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Infection | Products > Signaling Pathways > SARS-CoV | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Virus Protease

Product Information

• Catalog No.: HY-173521
• CAS No.: 3026520-19-1
• Molecular Formula: C28H21F2N5O2
• Molecular Weight: 497.50
• Purity: 99.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (10.05 mM); Clear solution
• Availability: In-stock

Source

Original product source