Dexpramipexole

Overview

Dexpramipexole ((R)-Pramipexole) is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole upregulates the expression of Parkin , PINK1 , GPX4 and FSP1 ; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na v 1.8 sodium channel ; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole induces mitophagy , inhibits ferroptosis , pyroptosis , apoptosis , neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Pain | Products > Disease Areas > Heart Disease | Products > Disease Areas > Allergic Asthma | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Sodium Channel | Products > Signaling Pathways > ATP Synthase | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > PINK1/Parkin

Product Information

• Catalog No.: HY-17355B
• CAS No.: 104632-28-2
• Molecular Formula: C10H17N3S
• Molecular Weight: 211.33
• Purity: 99.56%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (4.73 mM); Clear solution
• Availability: In-stock

Source

Original product source