Dexpramipexole-d 3 dihydrochloride

Overview

Dexpramipexole-d 3 ((R)-Pramipexole-d 3 ) dihydrochloride is the deuterium labeled Dexpramipexole. Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin , PINK1 , GPX4 and FSP1 ; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na v 1.8 sodium channel ; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy , inhibits ferroptosis , pyroptosis , apoptosis , neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Sodium Channel | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > ATP Synthase | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > PINK1/Parkin

Product Information

• Catalog No.: HY-17355BS
• CAS No.: 1432230-09-5
• Molecular Formula: C10H16D3Cl2N3S
• Molecular Weight: 287.27
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source