MS115 TFA

Overview

MS115 TFA is a selective PRMT5/MEP50 PROTAC degrader, with DC 50 values of 17.4 nM and 11.3 nM for PRMT5 and MEP50, respectively. MS115 TFA promotes PRMT5/MEP50 ubiquitination and degradation. MS115 TFA shows anticancer activity against breast cancer . (Pink: PRMT5 and MEP50 ligand ( HY-173562 ); Blue: VHL ligand ( HY-47070 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-173561A
• CAS No.: 3109377-61-6
• Molecular Formula: C65H89F4N11O15S
• Molecular Weight: 1372.53
• Purity: 99.98%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source