Nepafenac-d 5

Overview

Nepafenac -d 5 (AHR-9434-d 5 ; AL-6515-d 5 ) is the deuterium labeled Nepafenac ( HY-17357 ). Nepafenac , a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC 50 of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity ( IC 50 = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac ( HY-17479 ) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase ( COX ) enzymes and thereby decreasing the production of prostaglandin PGE ₂ . Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries.

Application

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Product Information

• Catalog No.: HY-17357S
• CAS No.: 1246814-53-8
• Molecular Formula: C15H9D5N2O2
• Molecular Weight: 259.31
• Purity: 98.84%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution
• Availability: In-stock

Source

Original product source