Clozapine N-oxide dihydrochloride

Overview

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di . Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor ( EC 50 =11 nM) agonist.

Application

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Product Information

• Catalog No.: HY-17366A
• CAS No.: 2250025-93-3
• Molecular Formula: C18H21Cl3N4O
• Molecular Weight: 415.74
• Purity: 99.59%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen)
• Solubility: ≥ 20 mg/mL (48.11 mM); Clear solution
• Availability: In-stock

Source

Original product source