RBN012811

Overview

RBN012811 is a highly selective PROTAC -based PARP14 degrader. RBN012811 forms a ternary complex with cereblon by binding to the NAD + site of PARP14 , and mediates the specific degradation of PARP14 via the ubiquitin-proteasome pathway ( IC 50 =10 nM). RBN012811 effectively depletes endogenous PARP14 in various cell lines and primary human macrophages, thereby downregulating IL-10 production and IFN-β mRNA levels, increasing phosphorylated STAT1 levels to enhance inflammatory signaling, and inhibiting interferon-induced ADPr condensate formation. RBN012811 also modulates viral replication, exhibiting increased HSV1 replication while reducing VSV replication. RBN012811 has important application value in research related to cancer and viral infections. (Pink: PARP14 Target protein ligand; Blue: Cereblon ligand ( HY-10984 ); Black: linker).

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Viral Infection | Products > Disease Areas > HSV Infection | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Integrin | Products > Signaling Pathways > HSV | Products > Signaling Pathways > VSV

Product Information

• Catalog No.: HY-173679
• CAS No.: 2569517-30-0
• Molecular Formula: C40H49FN8O6S
• Molecular Weight: 788.93
• Purity: 98.79%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution
• Availability: In-stock

Source

Original product source