Rofecoxib-d 5 is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor , with IC 50 s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 ( IC 50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
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