Manidipine dihydrochloride

Overview

Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist ( IC 50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel . Manidipine is widely applied to research of cardiovascular, metabolic disease and infection .

Application

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Product Information

• Catalog No.: HY-17403
• CAS No.: 89226-75-5
• Molecular Formula: C35H40Cl2N4O6
• Molecular Weight: 683.62
• Purity: 99.84%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (3.66 mM); Clear solution
• Availability: In-stock

Source

Original product source