PROTAC GPX4 degrader-4

Overview

PROTAC GPX4 degrader-4 is a GPX4 PROTAC degrader ( DC 50 : 5.32 nM). PROTAC GPX4 degrader-4 inhibits the activity of RT4, T24, and J82 cancer cells ( IC 50 values are 0.09, 2.97, and 7.58 μM, respectively). PROTAC GPX4 degrader-4 increases lipid ROS levels and induces ferroptosis in T24 and RT4 cells. PROTAC GPX4 degrader-4 has antitumor activity in T24 tumor-bearing BALB/c nude mouse model. PROTAC GPX4 degrader-4 can be used for bladder cancer research. (Pink: target protein ligand ( HY-N0193 ); blue: E3 ligase ligand (HY-1035960); black: linker ( HY-W013907 ); E3 ligase ligand + linker ( HY-174087 )). (Pink: GPX4 ligand ( HY-N0193 ); Blue: Cereblon ligand ( HY-103596 ); Black: linker ( HY-W013907 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > ROS Kinase

Product Information

• Catalog No.: HY-174086
• CAS No.: 3071165-43-7
• Molecular Formula: C43H58N2O13
• Molecular Weight: 810.93
• Purity: 99.68%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.53 mg/mL (3.12 mM); Clear solution
• Availability: In-stock

Source

Original product source