5-HT1A agonist 1 (Compound Ex.37) is a highly selective 5-HT 1a receptor agonist ( EC 50 =0.18 nM). 5-HT1A agonist 1 mimicks serotonin binding to the receptor, promotes postsynaptic membrane hyperpolarization, inhibits neuronal hyperexcitability, and reduces the release of anxiety-related neurotransmitters. 5-HT1A agonist 1 is promising for research of neuropsychiatric diseases.
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