NLRP3-IN-81

Overview

NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC 50 of 0.029 μM against cell pyroptosis induced by Nigericin ( HY-127019 ). NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1β . NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-174312
• CAS No.: 2922814-85-3
• Molecular Formula: C16H15F3N2O3S
• Molecular Weight: 372.36
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source