INNO-220

Overview

INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1α . INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α . INNO-220 disrupts the assembly and function of the CARD11 / BCL10 / MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11 . INNO-220 provides a new direction for lymphoma research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > MALT1 | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > Casein Kinase

Product Information

• Catalog No.: HY-174371
• CAS No.: 3032576-92-1
• Molecular Formula: C23H20N4O3
• Molecular Weight: 400.43
• Purity: 98.60%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source