Smurf1-IN-5

Overview

Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 ( SMURF1 ) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 ( bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP ( bone morphogenetic protein ) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > E1/E2/E3 Enzyme

Product Information

• Catalog No.: HY-174416
• CAS No.: 1824647-09-7
• Molecular Formula: C25H22ClFN4O3
• Molecular Weight: 480.92
• Purity: 99.98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution
• Availability: In-stock

Source

Original product source