RN341

Overview

RN341 is a specific type II kinase inhibitor of LRRK2 ( IC 50 : 296 nM). RN341 inhibits LRRK2 phosphorylation and avoids S935 dephosphorylation by stabilizing the open conformation. RN341 rescues LRRK2 -mediated kinesin motility block by preventing microtubule binding. RN341 effectively inhibits LRRK2 wild-type and G2019S mutant at the cellular level. RN341 provides a new direction for Parkinson's disease research .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > LRRK2

Product Information

• Catalog No.: HY-174427
• CAS No.: 3091508-57-2
• Molecular Formula: C30H34N8OS
• Molecular Weight: 554.71
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source